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Here SAM acts as a methyl donor which is actually formed with the help of vitamin B12

doi: 10.1016/j.carbpol.2018.07.054 [DOI] [PubMed] [Google Scholar] 57.Ahmad N, Ahmad R, Amir M, et al

This test measures levels of key neurotransmitters, such as serotonin, dopamine, and norepinephrine, which play critical roles in regulating mood, cognition, and overall mental health

Niacin or B3 Taking high-dose niacin supplements can result in skin-related allergic reactions, such as extreme facial flushing, also referred to as niacin flush. Flushing causes generalized itching and a burning sensation that is typically limited to the face and chest and lasts 20 to 30 minutes(1)