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A concentration of 3% of EDTA showed a reduction of approximately 50% in gilthead seabream parvalbumins IgE-reactivity to cod-allergic patients sera, however no changes regarding European seabass were observed with supplementations of up to 4.5% of EDTA

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Beyond biological evaluation, successful clinical translation of CQDs requires strict adherence to Good Manufacturing Practice (GMP) standards to ensure reproducibility, quality control, and patient safety throughout production [178]