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When taking B12 via injections or high doses of supplements, it bypasses the absorption limits of dietary B12, leading to a temporary rise in blood B12 levels

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The tricarboxylic acid (TCA) cycle breaks down the carbon substrate of acetyl-CoA, derived from pyruvate, amino acids, and fatty acids, generating carbon dioxide and reducing NAD + to NADH and FAD 2+ to FADH 2 (21) (see Figure 1 )