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It is more common in women, who make up nearly 80% of cases, with most diagnoses occurring around age 40

Phase 2 trials reported greater weight loss than either monotherapy

For example, Dorea , Bifidobacterium , and Ruminococcus torques are positively associated with SFN metabolite excretion, while members of the genus Blautia and Alistipes , on the contrary, are negatively associated ( Lactococcus , Bifidobacterium , Lactobacillus , Bacteroides , Pseudomonas , Staphylococcus , Enterococcus , and Streptomyces

Mechanistically, GHK-Cu has been shown to stimulate collagen and elastin synthesis in dermal fibroblasts, increase decorin (a small proteoglycan that helps regulate collagen organization), and influence matrix metalloproteinases and their inhibitors