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The catalase mechanism of action can be synthesized this way, according to chance ( 1952 a and b): If it is not neutralized, the H 2 O 2 interacts with iron cations (or copper), originating the ion hydroxil (inert) and the free radical hydroxil (active)

Through detailed biochemical and histological analysis of a maladaptive/pro-fibrotic cluster of proximal tubules, they discovered that cell necroptosis/ferroptosis is a vulnerable pathway in these pro-fibrotic cells