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An approved label is also different from a research protocol

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Dysfunction of the microbiota leads to decreased BA activity, reducing unconjugated BA and secondary BA production, weakening FXR activity, and exacerbating cirrhosis through various pathways: (1) In hepatocytes, FXR interacts with nuclear receptors such as peroxisome proliferator-activated receptors (PPAR)- and liver X receptor (LXR) to form heterodimers, regulating downstream target gene expression