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It should also be emphasized that the role of the gut microbiota in ASD remains the subject of lively debate, and recent studies point to significant conceptual and methodological limitations, including issues related to causality, reproducibility of results, and confounding variables, which should also be kept in mind when interpreting the existing research findings, particularly with respect to causal inference and reproducibility [134]

The Lewiston Tribune

Skewed CD44 expression and ceramide synthesis may contribute to declining epidermal barrier function and could represent key targets, beyond ECM rejuvenation, for improving skin function and appearance in midlife