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Protects collagen Oxidative stress breaks down collagen

A SINGLE-CENTER ANALYSIS Constance Mobley 1 Andrea Meinders 1 Elizabeth Brombosz 1 Enshuo Hsu 2 Mozhgon Moaddab 1 Ashish Saharia 1 Ashton Connor 1 Mark Hobeika 1 Caroline Simon 1 Yee Lee Cheah 1 Linda Moore 1 Victor Ankoma-Sey 3 Chukwuma Egwim 3 Tamneet Basra 1 Sudha Kodali 1 David Victor 1 Rafik Ghobrial 4 , 1 Houston Methodist Hospital, 2 University of Texas MD Anderson Cancer Center, 3 Liver Associates of Texas, 4 Houston Methodist JC Walter Transplant Center Background: Short- term mortality for patients with acute-on-chronic liver failure (ACLF) is high, around 90% at 3 months

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In this review, we highlight previous knowledge of oxidative stress, inflammation and functional features of gut microbiota in CKD, and review the role of microbial-derived metabolites in regulating inflammatory processes in CKD