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Melatonin stimulates cell apoptosis via the regulation of many apoptosis facilitators, including mitochondria, cytochrome c, Bcl-2, production of reactive oxygen species, and apoptosis receptors

[143] MitoFish and MitoAnnotator : a mitochondrial genome database of fish

Mishra A, Patni P, Hegde S, Aleya L, Tewari D

Over time, this oxidative insult accumulates and diminishes both follicle number and quality, presenting as premature menopause or a suboptimal response to ovarian stimulation