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Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB (2004) Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation

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This is not proof of clinical harm at therapeutic doses, but it provides a plausible mechanistic basis for concern

Collectively, these biochemical properties position forskolin as a valuable molecule for developing treatments aimed at reducing IOP, protecting against oxidative and inflammatory damage, and preserving neuronal health in various eye diseases (Figure 4)