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Currently, generally recognized is the multiple hit theory, which uses insulin resistance (IR) and obesity the first hit to increase free fatty acids (FFAs) and make the liver more susceptible to hepatotoxic injury

and LeBedis, C.A

4) Figure 4 described a resumptive overview of Wnt/-catenin signalling pathway targeted interventions in cancer therapy as follows: CPG049090, PKF115-584 and PKF222-815 are natural compounds that have been identified to disrupt the interaction of -catenin/TCF complex, suppressing the proliferation of colon cancer cells in vitro assays