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The anti-anginal drug trimetazidine reduces neutrophil-mediated cardiac reperfusion injury

However, this approach is notably less effective for individuals with chronic forms of thiamine deficiency-related disorders involving encephalopathies (see the section Wernicke Encephalopathy) (113) or TPK1 deficiencies

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Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans