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Abstract The brain renin-angiotensin system (RAS) has available the necessary functional components to produce the active ligands angiotensins II (AngII), angiotensin III, angiotensins (IV), angiotensin (17), and angiotensin (37)

In the pursuit of drug development, there are many constraints that must be satisfied as the pharmacokinetics, pharmacodynamics, safety and tolerable limits, delivering modalities and translatability from preclinical to clinical models (135)

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