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Can J Gastroenterol 2009;23:121125.ArticlePubMedPMCPDF 23

Specifically, activation of the TRPA1 receptor could be significant in several pathological situations given that it is known to be stimulated by a multitude of environmental irritants (including constituents of air pollution and burning vegetation), as well as endogenous products of oxidation which can be generated in the airways by inhalation of pollutants or during inflammation (Bessac et al., 2008

Those who use chewing tobacco usually let the wad or plug sit on the inside of their cheek

Clonogenic survival assay To assess colony survival, cell lines were exposed to e-cigarette extracts for 48 h, followed by another 48 h with e-cigarette extracts plus 2.5 M cisplatin doses