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In addition to the three inhibitor types, N -methyl-4-chloropyridine irreversibly inhibits NNMT based on suicide inhibition, where NNMT promotes its methylation and it subsequently reacts with C159 to inhibit NNMT (108)

The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise

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