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3.5.4 Macrophage ferroptosis and SLE Renal M2-like macrophages in LN patients selectively express CD163 (haptoglobinhemoglobin complex scavenger) and SLC40A1, tied to iron homeostasis (219, 220): 1) SLE-associated autoimmune hemolysis and glomerular injury-induced erythrocyte lysis generate excess haptoglobinhemoglobin complexes

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Nevertheless, in both cases new infectious viral particles will be released at the original site of infection, which will promote the infection of new epithelial cells within the surroundings and likely disseminate virus onto adjacent, non-infected neurons (Halford et al., HSV-1 Infection of the Central Nervous System Herpetic simplex encephalitis (HSE) is produced by the active replication of HSV-1 in neuronal cells in the brain (Gnann and Whitley, 2008