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More help Considerations for Potential Applications of the AOP (optional) Addressess potential applications of an AOP to support regulatory decision-making.This may include, for example, possible utility for test guideline development or refinement, development of integrated testing and assessment approaches, development of (Q)SARs / or chemical profilers to facilitate the grouping of chemicals for subsequent read-across, screening level hazard assessments or even risk assessment

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

Front Physiol 2015;6:187 5

Fait V, Sela S, Ophir E, Kreutzer H, Shnaider O, Perri A, et al