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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head

However, this review will not focus on drugs binding to the RBC membrane but on those that enter into the cell and bind to cytosolic components of RBCs

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Although the reactivity of haloacetyl-activated supports toward sulfhydryls is relatively selective, these can react with methionine, histidine, or tyrosine under appropriate conditions