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Compared with noncirrhotic liver, all cirrhotic specimens showed reduced expression of IGF-2R/M6PR protein

But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat

Acta Crystallogr sect D 79:449461 Akobeng AK, Singh P, Kumar M, Al Khodor S (2020) Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications