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10.7759/cureus.14284 Rohit Gupta, Maulin Patel, Luis Caceres, Mayur Rali, Parth Rali

In addition, long-term high levels of blood glucose come with lowered levels of glutathione

In order to alleviate ER stress, cells trigger the unfolded protein response (UPR) (Supplementary Box 1) , which serves as a critical cell survival mechanism, involving various adaptations, importantly including reduction of protein load via decreasing protein synthesis (see next section)