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However, no gene/pathway has been identified as unique to high-pressure adaptation, and recent findings suggest that piezophiles (microbes that thrive in high-pressure environments) employ a common adaptation strategy to cope with multiple types of stresses, such as starvation, acid, salt, temperature, oxidation, and osmosis, which may support survival at high pressure (Allemann et al., 2024

However, people who are more at risk of deficiency include those who drink excessive amounts of alcohol, women, the elderly, and people with thyroid disease (1)

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