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"Nicotinamide N-methyltransferase promotes excessive accumulation of fat and is a viable target for treating obesity." Nature Communications

Folate (B9) Target: Aim for upper third of local reference range Why it matters: B12 therapy increases demand on folate pathways and can expose low stores

12 Another crossover trial of eight women found reduced plasma concentrations of pro-inflammatory cytokines and overall symptoms when treated with 8 weeks of LDN, further supporting the hypothesis of LDN as an anti-inflammatory medication for fibromyalgia