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Description

J Biomol Screen 18, 851867

doi: 10.21037/atm.2016.08.53 26 SallustoFLanzavecchiaA

The synthesis of 5-HT is initiated by the rate-limiting enzyme tryptophan hydroxylase (TPH), which exists in two isoforms: TPH1, predominantly expressed in the gut enterochromaffin cells, and TPH2, primarily found in the central nervous system (CNS) (Imamdin and Van Der Vorst, 2023