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This expression vector allows expression and secretion of a protein of the invention by virtue of the strong AOX1 promoter linked to the Pichia pastoris alkaline phosphatase (PHO) secretory signal peptide (i.e., leader) located upstream of a multiple cloning site

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Of these 7 patients, 4 succumbed to the disease (57.14%), 2 were alive with disease stability (28.57%), and 1 was not reported