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Sensitivity was determined by comparing mean radial growth from 3 replicates, significance was determined via one-way ANOVA

While ALT levels were significantly elevated at 48 h in the rat (as they were in the mouse), indicative of substantial hepatocellular damage, the degree of overt liver tissue degeneration was low (in contrast to the mouse) as assessed by histopathology, thus allowing robust proteomic analysis

Among the various active components of PV, ursolic acid exhibited the strongest anti-ferroptosis activity