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Since then, many small, short-term studies have reported an increased risk for biochemical vitamin B12 deficiency in patients taking metformin, with an incidence ranging from 5.6% to 36%.2-4 A large long-term study published in 2016 reaffirmed that B12 deficiency affects a small but significant proportion of patients taking metformin.5 This study analyzed data on 1,800 participants from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study who were at high risk for T2DM

Taking glutathione with food On the other hand, taking glutathione with food may offer some benefits: Reduced stomach irritation: Some people may experience mild stomach discomfort when taking supplements on an empty stomach

In research observations, occasional non-specific findings such as mild gastrointestinal disturbance have been noted with oral administration of peptide compounds in general

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