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Reactive oxygen species are natural byproducts of cellular metabolism and require ongoing regulation by antioxidant systems to help maintain balance and limit oxidative stress

Additional enzymatic activity such as proteolytic cleavage, phosphorylation, methylation, and ubiquitinylation may occur as a result of these signaling pathways

Liraglutide up-regulation thioredoxin attenuated Mller cells apoptosis in high glucose by regulating oxidative stress and endoplasmic reticulum stress

DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request