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336 While cell-based display methods typically create the genotype to phenotype linkage through compartmentalization, CFE-based selection methods, like ribosome 337 and mRNA 338 display, frequently leverage a direct physical link between a displayed protein and its transcript to maintain the genotype and phenotype linkage

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This said, the cytoplasmic facing ankyrin-repeat domains of zDHHC13 and 17 are involved in determining the substrate specificity of these enzymes (53, 54)

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