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Another study investigated the potential therapeutic benefits of curcumin derivative GT863 for ALS

The hormetic effect of micronutrients in general has been abundantly demonstrated, where both deficiency and excess can cause detrimental effects and physiological (relatively lower) doses are beneficial, but higher doses may do damage.26 A similar principle can be applied to antioxidants, including bioactive compounds or phytonutrients.27 Multiple antioxidant micronutrients, including vitamin C, have been shown to take on prooxidative qualities in higher dosages.28 These riskier higher dosages are unlikely to be from antioxidants sourced from whole foods in a balanced diet with intake at physiological levels and more commonly appear with supplementation

Depression, anxiety and stress during COVID-19: associations with changes in physical activity, sleep, tobacco and alcohol use in Australian adults

[DOI] [PubMed] [Google Scholar] 71.Mir A.R., Moinuddin, Habib S., Khan F., Alam K., Ali A