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To ensure drug safety and efficacy, interdisciplinary cooperation is required, including biology, pharmacology, clinical medicine, etc

In most of the responses to stress, the plant promotes an increase in reactive oxygen species (ROS) (Dias et al., 2011

Wang L , Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H

5 Disruption of the neuroendocrine network and the local biochemical microenvironment The pathological microenvironment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) involves not only inflammatory-immune crosstalk and oxidative stress, but alterations in local biochemical components and dysregulation of the neuroendocrine network also represent crucial links in the impairment of sperm development