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RNA aptamers specifically targeted CD40(CD40Apt) in TED mice, thereby significantly inhibiting the CD40-CD40L pathway

The study assessed various clinical and biochemical markers, including body weight, body mass index (BMI), waist circumference (WC), total fat mass, and visceral fat, as well as such inflammatory markers as the PASI and the Disease Activity Index of Psoriatic Arthritis (DAPSA)