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Reconstitution sterility and refrigerated storage (28C) are the actual high-risk variables

Growing evidence suggests that CRC cells exploit specific metabolic adaptation mechanisms to cope with the microenvironments of distant organs, thereby enhancing their invasiveness and metastatic colonization capacity

Interestingly, these changes to fibril deformation mechanics did not correspond to changes in fibril modulus and, thus, lend further support to the previous findings that AGE-derived mechanical changes are likely driven by changes at a larger scale, such as fiber-fiber sliding (Fessel et al ., 2014