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The most critical factors to consider when preparing a siRNA delivery system are the binding ability, stability, and release of siRNA

Funding This work was supported by the National Natural Science Foundation of China (grant number: 82000086), the Shanghai Sailing Program (grant number: 20YF1440300) for WG, the National Natural Science Foundation of China (grant number: 81870064, 82070086) for QL, and the Shanghai Jiao Tong University Medical & Engineering Cross Fund (grant number: YG2019QNA65) for HH

But some of you struggle with the opposite: low blood pressure (hypotension)

And if you do have a condition that significantly inhibits your ability to absorb B12, like pernicious anemia, you likely need injected B12 supplements