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while the JNK signaling pathway is associated with apoptosis and proinflammatory cytokines 84

Epigenetic heterogeneity within tumors and treatment-driven clonal evolution Epigenetic heterogeneity within tumors is a major driver of treatment failure [196], with plasticity far exceeding that of genomic mutations, making it a key force in adaptive evolution [6]

GR often plays an important role in the protection of plants from temperature stresses by preventing the oxidation of enzymes and membranes 42

for example, while the H3K27me3 modification deposited by the PRC2 complex can silence genes, its fidelity during cell division is limited [163, 223]