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[DOI] [PMC free article] [PubMed] [Google Scholar] 195.Osei-Owusu, H

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NR restores the age-associated decline in the metabolic cycle and circadian behavioral, including the BMAL1 activity, oscillation mitochondrial respiration, rhythmic transcription and late evening activity to youthful levels

These data suggest that erastin treatment can induce two opposing effects on SLC7A11 transcription: transcriptional activation (through a still unknown mechanism) and transcriptional repression (through decreasing H2Bub occupancy on the SLC7A11 promoter (Wang et al., 2019b) and potentially activating ATF3 (Wang et al., 2020a)]