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A PD pump curve usually has a separate axis detailing viscosity, where the pump will show a flow against viscosity as per the graph below

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Indeed, diversity could be an advantage if it were to allow directing the pharmacological stimuli towards those receptors that are specifically involved in analgesic responses and whose cellular location and/or effector association would make them more resistant to progressive waning of signalling efficacy

In healthy adults, its activity declines with age, contributing to the progressive loss of synaptic density and cognitive flexibility that most people experience starting in their 40s and 50s