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Polyphenols, Nrf2, and Proteostasis One of the elegant mechanisms that cells have adapted to protect themselves against oxidative stress and other insults is Nrf2 pathway and the binding of this master transcriptional regulator with antioxidant response element (ARE) in the regulatory region of many genes, which leads to the expression of several enzymes with antioxidant and detoxification capacities

[DOI] [PMC free article] [PubMed] [Google Scholar] 291.Cohen L, Sekler I, Hershfinkel M

Implications of Glutathione Deficiency A glutathione deficiency has been linked to several digestive-related conditions, such as leaky gut (mentioned above) as well as gut dysbiosis and chronic inflammation

This finding reaffirms a critical link between neuroendocrine disturbance and glutamate transmission in bipolar disorder, implicating this key area involved in memory, emotional regulation, and stress response