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Given the critical role of the mitochondrial-dependent pathway in other forms of ischaemia/reperfusion injury, such as ischaemic stroke, we evaluated B-017 in focal cerebral ischaemia

5.3 Activator of antioxidant enzymes The utilization of antioxidant activators in the treatment of CNS diseases is multifaceted, targeting the modulation of key signaling pathways to enhance cellular antioxidant defenses

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Epidemiology, neurobiology and pharmacological interventions related to suicide deaths and suicide attempts in bipolar disorder: Part I of a Report of the International Society for Bipolar Disorders Task Force on Suicide in Bipolar Disorder