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doi: 10.1152/physrev.1978.58.2.317 76 RochetteLDogonGRigalEZellerMCottinYVergelyC

Psychiatry 8 , 173 (2018)

Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45