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However, we note that the folic acid and vitamin B-12 handling by the kidney is tightly coordinated: The expression of the high-affinity folate receptors (i.e., FR- and FR-) on the epithelial membrane coincides with that of megalin and cubulin (5860)

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In its main 56-week clinical trial, patients on the highest dose lost an average of 8 percent of their starting body weight