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The library spans five distinct warhead classes, including epoxides, vinyl sulfones, acrylamides, -cyanoacrylamides, and a core set of SAr-reactive heteroarenes

Similar effects are seen with other GLP-1 medications like Wegovy and Saxenda

The accumulation of NADPH autofluorescence over time is an indicator of aconitase activity, where ACO1/2 present in the sample converts the supplied citrate to isocitrate, which is subsequently metabolized by the supplied IDH1 in a reaction that yields NADPH