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Description

Importantly, defective tRNAs can lead to the accumulation of damaged and unfolded mitochondrial proteins, 289,290 suggesting that targeting mt-ISR could be a potential therapeutic strategy for MERRF and other mitochondrial disorders caused by tRNA defects

PLoS ONE 3(5):e2117

10.1002/ange.202006941

A study of 8,943 patients with impaired glucose tolerance demonstrated that for every 1 mmol/L increase in fasting blood glucose, the risk of AF increased by 33%, indicating that elevated blood glucose levels may contribute to AF even before diabetes is diagnosed (Latini et al., 2013)