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The tumor suppressor p53 and its downstream targets regulate ferroptosis, which is another significant mechanism

Src family members participate in a variety of signaling processes, including mitogenesis, T- and B-cell activation, cell differentiation and proliferation, as well as cytoskeleton restructuring, through the activation of an array of downstream effectors such as PI3K, phospholipase C, and FAK (1087)

doi: 10.3390/pathogens3010014 170 RodriguezCMayoJCSainzRMAntolnIHerreraFMartnVet al

1.2.4 Microenvironment-driven epigenetic reprogramming The TME plays a crucial role in driving epigenetic reprogramming in T cells, a process that profoundly affects the exhaustion process and functional state of T cells (36, 59)