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That does not mean it has no effect, but it does mean the evidence should be evaluated honestly rather than through clinic marketing

For example, in a focal ischemia model, mTORC1 is downregulated in the ischemic nucleus, but mTORC1 is upregulated in the ischemic penumbra (Wu et al., 2017

A notable example is vitamin C (ascorbic acid) and its stable derivative, L-ascorbic acid 2-phosphate, which significantly enhance the proliferative capacity and effector functions of T cells, a unique subset of T lymphocytes that bridge innate and adaptive immunity