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33 The expression by BC cells of cyclo-oxygenase-2 (COX-2), the epidermal growth factor receptor (EGFR) ligand HBEGF, and 2,6-sialyltransferase (ST6GALNAC5) has been shown to mediate passage across the BBB

The target proteins IGF-1 (Santa Cruz Biotechnology, Heidelberg, Germany), p-IGF-1R (Cell Signaling Technology, Danvers, MA, USA), Ly6G and -arrestin1 (Abcam, Cambridge, MA, USA) were then detected using secondary antibodies, followed by the ABC staining system, and the sections were counterstained with hematoxylin

This suggests that FOXO4-DRI may selectively target and eliminate senescent cells, potentially alleviating some dysfunctions associated with aged Leydig cells, such as reduced testosterone synthesis

The nicotin in the name is from vitamin B3 etymology