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For instance, a propensity to make an excessively intense innate immune response, or on the contrary the unability to control an infection, the pathogen persistence (potentially due to the previous cause), or a suboptimal functioning of mitochondria, leading to an excess production of reactive oxygen species (ROS), or a suboptimal functioning of the neurovegetative nervous system, facilitating the triggering of dysautonomia, or a propensity do develop autoimmune diseases

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The authors suggest that adequate vitamin B6 levels may avert psychological distress during emotional situations, such as grieving, by regulating serotonin levels.[47] Cardiovascular Support Elevated levels of homocysteine have been identified as an independent risk factor for coronary artery disease.[48] Independent of its place in the methylation cycle, evidence also suggests that homocysteine is in itself a toxic compound that can directly promote atherosclerosis, neuronal damage and mood disturbances.[49] Therefore, hyperhomocysteinaemia is not only a marker of reduced methylation status, but also a direct pathogenic agent