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Major advances in the management of relapsed/refractory multiple myeloma include BCMA-targeting treatments such as the CAR-T therapies ciltacabtagene autoleucel and idecabtagene vicleucel, and the bispecific antibodies teclistamab, elranatamab, and linvoseltamab

For tirzepatide, subcutaneous administration is required

Environmental and behavioral strategies include: Maintaining cooler ambient temperatures and using fans or air conditioning Wearing layered, breathable clothing made from natural fibers like cotton Avoiding known triggers such as spicy foods, caffeine, alcohol, and hot beverages Staying well-hydrated throughout the day Maintaining a healthy sleep environment with cool temperatures and moisture-wicking bedding Evidence-based non-pharmacologic approaches include cognitive behavioral therapy (CBT) and clinical hypnosis, which have demonstrated effectiveness for vasomotor symptoms

This renders the tissue more vulnerable to minor trauma and inflammatory triggers that would normally be well tolerated