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Mitochondrial dysfunction may evolve over time or vary across different stages of hEDS, but current cross-sectional studies do not capture these dynamics

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Evidence supports multiple evidence-informed approaches depending on individual tolerance and biomarker context

Various Positron Emission Tomography (PET) studies using radiotracers that measure these proteins in the brain, including [11C]-Pittsburgh Compound B (PiB), [18F]-Florbetaben (FBB), or [18F]-florbetapir ([18F]-AV-45), revealed significant increased retention and standardized uptake value ratios (SUVR) in PD APOE4 carriers than non-carriers (See Table 1 for more details) (Maetzler et al., 2009