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Consistent concentration: a fixed 5mg/ml reference point simplifies study design and replicate-to-replicate comparison

Practically this means that the infant need to be fed often during the first days to stimulate the milk coming in

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As described in the Regulatory Impact Analysis of the CY 2025 PFS proposed rule (89 FR 62183), accounting for the impact of improper payments on performance year expenditures and factors used to calculate updated historical benchmarks would not result in an increase in spending beyond the expenditures that would otherwise occur under the statutory payment methodology in section 1899(d) of the Act