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Additionally, metal ion metabolism disturbances are the basis for the onset of various neurological diseases [175]

The addition of ImmTOR to pegadricase results in a dose-dependent reduction in ADAs corresponding with prolonged serum enzyme activity and maintenance of low sUA levels

4) GPX4-independent ferroptosis suppressionDHODHCoQ10H 2 pathway in the mitochondria: Dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme localized to the mitochondrial inner membrane, catalyzes the fourth step of pyrimidine biosynthesisconverting dihydroorotate (DHO) to orotate (OA)while transferring electrons to mitochondrial ubiquinone, reducing it to CoQ10H 2 , which acts as a radical-trapping antioxidant (107)

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